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Integrating Developability Assessment into Lead Optimisation: Chemistry and Pharmaceutical Aspects – Hosted by Evotec

April 21 @ 11:00 am12:00 pm

Designing and selecting appropriate lead candidates is key in reducing clinical attrition and costs associated with the development of new drugs. To ensure a smooth transition between the Discovery and Development phases, the ONE Evotec organization has implemented dedicated processes during the lead optimization phase for chemistry and pharmaceutical aspects. These processes cover synthesis route scouting and scale up, solid form optimization screening, solubility and stability profiling as well as overall biopharmaceutical evaluation to identify the best development candidates. This includes not only aligning experimental protocols and the definition of appropriate criteria, but also reinforced interactions and close communication between Discovery and Development experts for data cross –review, thus ensuring data-based decision making and the implementation of mitigation plans when a candidate transitions into development.


April 21
11:00 am – 12:00 pm