Systemic lupus erythematosus (SLE), the most common type of lupus, is an autoimmune disease that affects a variety of tissues, including joints, skin, brain and kidneys.
Professor Jacques Banchereau at The Jackson Laboratory has led a multi-institutional team that profiled more than 360,000 cells from children and adult SLE patients and healthy controls, finding a distinctive interferon gene expression signature across a wide variety of blood cells.
The data provides a road map for further exploration and identifies potential targets for therapeutic development.