Yale researchers have developed a new way to efficiently engineer immune cells, an advance which enhances the ability to fend off cancer and other diseases.
A Yale team headed by Sidi Chen, assistant professor of genetics and in the Systems Biology Institute, utilize a system that relies on the cell’s own repair machinery to integrate new genes into its genome. They used a single protein capable of snipping sections of the genome at multiple points and a repurposed virus to introduce modified genes at specific locations. more