Many health problems in the developed world stem from the disruption of a delicate metabolic balance between glucose production and energy utilization in the liver.
Now a Yale team led by senior author Gerald Shulman and first author Rachel Perry, both endocrinologists, report in the journal Nature that they have discovered the molecular mechanisms that trigger metabolic imbalance between these two distinct but linked processes, a finding with implications for the treatment of diabetes and non-alcoholic fatty liver disease. more