Unabated glucose production from the liver is one of the key mechanisms of diabetes. Through better understanding how metformin works to suppress gluconeogenesis, Yale researchers hope to prepare the way for more effective drugs with fewer side effects.
Gerald Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, recently published his lab’s findings on how metformin works to suppress gluconeogenesis through inhibiting Complex IV activity.
A different study, led by Yingqun Huang, MD, PhD, professor of obstetrics, gynecology & reproductive sciences, builds upon Shulman’s findings and further illuminates how the drug works.